Does measurement of exercise/rest calf muscle perfusion reserve with first-pass contrast-enhanced MRI in peripheral arterial disease perform better than exercise-only perfusion ?
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چکیده
منابع مشابه
Does measurement of exercise/rest calf muscle perfusion reserve with first-pass contrast-enhanced MRI in peripheral arterial disease perform better than exercise-only perfusion ?
Methods Sixteen healthy subjects and 3 symptomatic PAD patients (ABI 0.4-0.9) underwent contrast-enhanced perfusion MRI of the calf before and after plantar-flexion exercise using an MR-compatible pedal at 50 rpm for up to 20 minutes or until limiting symptoms. Contrast-enhanced first-pass images were obtained on a 3T Siemens Trio scanner by infusion of 0.1mM/kg of gadolinium-DTPA followed by a...
متن کاملCalf muscle perfusion maps from contrast-enhanced magnetic resonance imaging (CE-MRI) to assess peripheral arterial disease
Background Peripheral arterial disease (PAD) is associated with impaired function of the lower extremities, manifested clinically as intermittent claudication or rest pain. Previous studies have suggested that alterations in microcirculation due to a paucity of collateralization may contribute to functional impairment in PAD patients. Therefore, small vessel blood flow at the level of leg muscl...
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First-pass contrast-enhanced (CE) myocardial perfusion imaging will experience T(2) (*) effects at peak concentrations of contrast agent. A reduction in the signal intensity of left ventricular (LV) blood due to T(2) (*) losses may effect estimates of the arterial input function (AIF) used for quantitative perfusion measurement. Imaging artifacts may also result from T(2) (*) losses as well as ...
متن کاملArterial spin labeling MRI to measure peak-exercise calf muscle perfusion reproducibly discriminates peripheral arterial disease from normal
Background Prior work demonstrated the utility of first-pass gadolinium-enhanced calf muscle perfusion MRI in patients with peripheral arterial disease (PAD). However patients with PAD often have advanced renal disease which prohibits the use of gadolinium-based contrast agents due to the concern for nephrogenic systemic fibrosis. ASL for quantification of calf muscle blood flow could provide a...
متن کاملDeterminants of exercise calf muscle perfusion in Peripheral Arterial Disease (PAD)
Background In patients with PAD, ankle-brachial index (ABI) does not correlate well with time to claudication and lacks the ability to quantify tissue perfusion, therefore limiting the development of new therapies. Arterial spin labeling (ASL) MRI is a novel non-contrast technique that measures peak calf muscle perfusion noninvasively at a microvascular level. We sought to analyze the relations...
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ژورنال
عنوان ژورنال: Journal of Cardiovascular Magnetic Resonance
سال: 2011
ISSN: 1532-429X
DOI: 10.1186/1532-429x-13-s1-p385